parecoxib + loxoprofen

Parecoxib + loxoprofen is a sequential analgesic regimen consisting of an initial intravenous dose of parecoxib followed by a multi-day course of oral loxoprofen. This specific combination was evaluated by Peking Union Medical College Hospital in a randomized, non-inferiority clinical trial for the management of postoperative pain in patients undergoing transnasal transsphenoidal surgery for pituitary adenomas. Parecoxib is a sulfonamide-based prodrug of valdecoxib that acts as a selective cyclooxygenase-2 (COX-2) inhibitor, providing rapid pain relief via intravenous administration. Loxoprofen is a non-selective propionic acid derivative NSAID that inhibits both COX-1 and COX-2 enzymes, maintaining analgesia through oral administration. The regimen is designed to provide effective multimodal analgesia while minimizing the need for opioid medications like tramadol.

Other names

NSAID regimen (Peking Union Medical College Hospital)parecoxib and loxoprofen