parecoxib + remifentanil

Parecoxib + remifentanil is a multimodal analgesic regimen used primarily in the perioperative setting to manage acute postoperative pain. Parecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor and a prodrug of valdecoxib, which reduces prostaglandin synthesis to provide anti-inflammatory and analgesic effects. Remifentanil is a potent, ultra-short-acting synthetic mu-opioid receptor agonist characterized by rapid onset and offset due to its metabolism by non-specific tissue and plasma esterases. The combination is frequently employed in "opioid-sparing" strategies, where the administration of a non-opioid analgesic like parecoxib allows for a reduction in the required dose of remifentanil, thereby potentially minimizing opioid-related side effects such as respiratory depression, nausea, and vomiting while maintaining effective analgesia.

Other names

parecoxib and remifentanil