Drug intelligence / Profile preview

passiflora incarnata + isoflavone

Development stage
Discontinued
Lead developer
Ache Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

A combination product containing **standardized extracts of Passiflora incarnata (passion flower)** and **isoflavones (plant-derived phytoestrogens, often extracted from soy)**. This combination has been developed for the treatment of **climacteric (menopausal) symptoms** in women who prefer non-hormonal, plant-based therapies. - **Passiflora incarnata** contains active flavonoids such as vitexin and a benzoflavone moiety, conferring anxiolytic, sedative, and possible hormone-modulating effects by influencing serotonin and GABAergic neurotransmission, and by decreasing monoamine oxidase activity[2][3][4]. - **Isoflavones** act as phytoestrogens, providing mild estrogenic activity, which may reduce vasomotor symptoms and support bone and cardiovascular health in postmenopausal women[1]. The combination is aimed at providing **relief of menopausal symptoms** such as hot flashes, insomnia, mood swings, and anxiety, in postmenopausal women, especially those seeking alternatives to hormone replacement therapy[1][4].

Other names
Passiflora incarnata and isoflavone combinationPassiflora incarnata and isoflavona combination
02

Targets

SERT (Sodium-dependent serotonin transporter)GABA-B (Gamma-aminobutyric acid receptor type B)GABRR (GABA-A receptor subunit rho)

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