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pazopanib + CapeOx
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
The combination **pazopanib + CapeOx** consists of oral pazopanib, a small molecule multitargeted tyrosine kinase inhibitor, plus the CapeOx chemotherapy regimen (capecitabine and oxaliplatin). **Pazopanib** inhibits angiogenesis by targeting the vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3), platelet-derived growth factor receptors (PDGFR-α and PDGFR-β), and c-kit, thereby preventing tumor blood vessel formation and growth. **CapeOx** combines the antimetabolite capecitabine (an oral prodrug of 5-fluorouracil) with oxaliplatin, a platinum-based DNA crosslinker, inhibiting cell replication. This combination was investigated primarily as a first-line treatment for advanced or metastatic gastric cancer, where it demonstrated moderate anti-tumor activity and a manageable toxicity profile in phase II studies[1][2][4].
- Brand names
- VotrientNone
- Other names
- pazopanib plus CapeOxpazopanib plus capecitabine and oxaliplatinpazopanib/CapeOx
02
Targets
VEGFR2 (Vascular endothelial growth factor receptor 2)TS (Thymidylate synthase)KIT (c-KIT proto-oncogene receptor tyrosine kinase)PDGFRB (Platelet-derived growth factor receptor beta)DNAVEGFR3 (Vascular endothelial growth factor receptor 3)VEGFR-1 (Vascular endothelial growth factor receptor 1)PDGFRA (Platelet-derived growth factor receptor alpha)
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