peanut oral immunotherapy (UNC Chapel Hill)

Peanut oral immunotherapy (OIT) is an investigational treatment for peanut allergy developed and studied by the University of North Carolina at Chapel Hill. The therapy involves the daily oral administration of gradually increasing doses of peanut protein, typically in the form of peanut flour, to induce immunological desensitization. This process aims to increase the threshold of peanut protein required to trigger an allergic reaction, thereby reducing the risk of severe reactions such as anaphylaxis from accidental exposure. UNC's research specifically focuses on the cellular and molecular mechanisms of desensitization, including changes in immune cell populations and antibody profiles, and explores salvage therapies for patients who have lost desensitization.

Other names

Peanut OITPeanut flourOpen label peanut OIT