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pegylated liposomal doxorubicin + pembrolizumab
- Development stage
- Unknown
- Lead developer
- Johnson & Johnson
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
A combination therapy consisting of pegylated liposomal doxorubicin (PLD) and pembrolizumab. PLD is a formulation of doxorubicin encapsulated in pegylated liposomes that enhances its immune modulatory effects by redirecting cellular drug uptake to phagocytic cells[5]. Pembrolizumab is a PD-1 inhibitor that blocks the interaction between PD-1 and its ligands, activating T-cell-mediated immune responses against tumor cells[6]. The combination is being investigated primarily for platinum-resistant ovarian cancer, with preclinical evidence suggesting PLD may synergize with immune checkpoint blockade[1].
- Brand names
- KeytrudaDoxilCaelyx
- Other names
- PLDpembrolizumab + PLDpembrolizumab + pegylated liposomal doxorubicin hydrochloride
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)TOP2A (DNA topoisomerase II)DNA
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