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Drug intelligence / Profile preview
pembrolizumab + gemcitabine + docetaxel
- Development stage
- Phase 2
- Lead developer
- Merck
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Intravesical
01
Overview
This combination regimen consists of systemic **pembrolizumab** (an anti-PD-1 monoclonal antibody) and intravesical chemotherapy using **gemcitabine** and **docetaxel**. It is specifically being investigated for patients with high-risk non-muscle invasive bladder cancer (NMIBC) who are unresponsive to or have been exposed to Bacillus Calmette-Guérin (BCG) therapy. Pembrolizumab works by blocking the PD-1/PD-L1 pathway to enhance the immune response against tumor cells, while gemcitabine and docetaxel provide local cytotoxic effects within the bladder. The regimen is currently being evaluated in a Phase II study sponsored by the Bladder Cancer Latin American Group (BLATAM).
- Other names
- Gemcitabine/Docetaxel + PembrolizumabGem/Doce + Pembrolizumab
02
Targets
DNAPDCD1 (Programmed cell death protein 1 receptor)TUBB (Tubulin (alpha and beta subunits))
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