perindopril + indapamide (Servier)

Preterax is a fixed-dose combination small molecule drug consisting of the angiotensin-converting enzyme (ACE) inhibitor perindopril and the thiazide-like diuretic indapamide. Developed by Servier, it is indicated for the treatment of essential hypertension and for the reduction of cardiovascular and renal risks in patients with type 2 diabetes mellitus. The combination leverages the complementary mechanisms of its components: perindopril reduces systemic vascular resistance by inhibiting the conversion of angiotensin I to the potent vasoconstrictor angiotensin II, while indapamide promotes sodium and water excretion in the distal convoluted tubule. This dual approach provides superior blood pressure control and target organ protection compared to monotherapy, as demonstrated in major clinical trials such as ADVANCE and PREMIER.

Brand names

PreteraxBiPreteraxNoliprelCoversyl PlusAceon Plus

Other names

perindopril/indapamideperindopril arginine + indapamideperindopril erbumine + indapamide