Perioglas + A-PRF

Perioglas + A-PRF is a combination regenerative therapy used in dental and periodontal surgery. It consists of PerioGlas, a bioactive glass alloplastic bone graft material, and Advanced Platelet-Rich Fibrin (A-PRF), an autologous platelet concentrate derived from the patient's blood. **PerioGlas** acts as an osteoconductive scaffold that bonds to bone and soft tissue, facilitating new bone formation by eliciting a specific biological response at the graft site[1][2]. **A-PRF** is produced by centrifuging the patient’s blood to yield a fibrin matrix rich in platelets, leukocytes, growth factors (such as PDGF, TGF-beta), and cytokines. This matrix promotes wound healing and tissue regeneration through slow release of these factors over several days[5][6]. The combination is used primarily for periodontal regeneration—including treatment of intrabony defects, extraction sockets, sinus elevation surgeries, ridge augmentation procedures, peri-implantitis management—and has been shown to enhance clinical outcomes such as pocket depth reduction and increased bone fill compared to open flap debridement alone[2][3][4]. The synergistic effect results from both the osteoconductive properties of PerioGlas and the bioactive stimulation provided by A-PRF.

Other names

PerioGlas + Advanced Platelet-Rich FibrinPerioGlas + A-PRF