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peripheral blood stem cells + hyaluronic acid
- Development stage
- Unknown
- Lead developer
- Kuala Lumpur Sports Medicine Center
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intraarticular
01
Overview
Peripheral blood stem cells + hyaluronic acid (PBSC + HA) is an investigational regenerative combination therapy developed by the Kuala Lumpur Sports Medicine Centre (KLSMC). The treatment involves the intra-articular injection of autologous peripheral blood stem cells—which contain mesenchymal stem cells capable of differentiating into chondrocytes—in combination with hyaluronic acid, which serves as a bioactive scaffold and lubricant. This procedure is typically performed following arthroscopic subchondral drilling (microfracture) to facilitate the repair of ICRS grade 3 and 4 chondral lesions in the knee. The therapy aims to regenerate hyaline-like articular cartilage, improving joint function and reducing pain in patients with articular cartilage disorders.
- Other names
- PBSC + HAautologous peripheral blood stem cells + hyaluronic acid
02
Targets
RHAMM (Hyaluronan-mediated motility receptor)CD44 (CD44 antigen)
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