Drug intelligence / Profile preview

Perisolv + hyaDent BG

Development stage
Unknown
Lead developer
REGEDENT
Modality
Hydrogel Systems → Drug Delivery Systems, Small Molecules
Administration
Dental, Subgingival, Periodontal, Topical
01

Overview

Perisolv + hyaDent BG is a combination therapy used in dental and periodontal care, particularly for the non-surgical treatment of periodontitis, peri-implant mucositis, and peri-implantitis. The protocol involves sequential application of two products: - **Perisolv** is a debridement gel containing sodium hypochlorite and amino acids. It acts as a biofilm eraser by softening and degrading bacterial biofilm on tooth roots or implant surfaces, enhancing the effectiveness of mechanical debridement. - **hyaDent BG** is a sterile gel composed primarily of cross-linked hyaluronic acid (xHyA). Applied after debridement, it supports tissue regeneration by stabilizing blood clots, attracting growth factors, coordinating inflammation resolution, accelerating angiogenesis (new blood vessel formation), and providing bacteriostatic protection. This combination forms the basis of the CLEAN&SEAL concept—a clinically validated protocol designed to improve clinical outcomes in both surgical and non-surgical management of periodontal and peri-implant diseases. Clinical studies have shown that this approach leads to greater reductions in probing depth and improved healing compared to mechanical debridement alone[7][9][3].

Other names
CLEAN&SEAL

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