pethidine + dexamethasone

Pethidine + dexamethasone is a combination of two pharmaceutical agents used primarily in the perioperative setting, particularly for the prevention and management of postoperative shivering. Pethidine (also known as meperidine) is a synthetic opioid analgesic that acts mainly as an agonist at the mu-opioid receptor, providing both analgesia and anti-shivering effects, likely through direct action on thermoregulatory centers or opioid receptors. Dexamethasone is a potent synthetic glucocorticoid corticosteroid with strong anti-inflammatory and immunosuppressive properties; it reduces shivering by decreasing the core-to-skin temperature gradient via its anti-inflammatory action and inhibition of vasoconstrictors and pyrogenic cytokines. The combination has been shown to be effective in reducing postoperative shivering compared to placebo or either agent alone[1][3][2]. Both drugs are widely used individually for various indications—pethidine for pain relief and shivering control, dexamethasone for inflammation, immune modulation, nausea/vomiting prevention, and other perioperative uses.

Other names

meperidine + dexamethasone