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petiveria alliacea extract (Hospital Universitario San Ignacio)
- Development stage
- Unknown
- Lead developer
- Pontificia Universidad Javeriana
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Petiveria alliacea extract, branded as Esperanza, is a standardized phytomedicine developed by Hospital Universitario San Ignacio in collaboration with Pontificia Universidad Javeriana. The drug is an aqueous extract obtained from the leaves of the Petiveria alliacea plant, produced under GMP conditions. Its primary mechanism of action involves the inhibition of tumor metabolism by disrupting both glycolysis and oxidative phosphorylation (OXPHOS). It is currently being evaluated in Phase Ib/II clinical trials as a combination therapy with standard chemotherapy for patients with metastatic gastrointestinal tumors (including gastric, colorectal, pancreatic, and biliary tract cancers) and acute leukemias (AML and ALL).
- Brand names
- Esperanza
- Other names
- Petiveria alliacea extract
02
Targets
PR (Progesterone receptor)
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