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Pfizer Research & Development GPR61 compound 15
- Development stage
- Unknown
- Lead developer
- Pfizer
01
Overview
Pfizer Research & Development GPR61 compound 15: sourced facts only. name: "The cryogenic electron microscopy structure of GPR61 bound to compound 15 shows that this class of inverse agonists binds to an induced, intracellular, allosteric pocket and abolishes GPR61 constitutive activity by disrupting its interactions with G protein, representing a novel mode of action of GPCR inverse agonism." [PMID:41834467]; target: "The cryogenic electron microscopy structure of GPR61 bound to compound 15 shows that this class of inverse agonists binds to an induced, intracellular, allosteric pocket and abolishes GPR61 constitutive activity by disrupting its interactions with G protein, representing a novel mode of action of GPCR inverse agonism." [PMID:41834467]; developer: "Pfizer Research & Development, 558 Eastern Point Rd, Groton, Connecticut 06340, United States." [PMID:41834467]
02
Targets
GPR61 (G protein-coupled receptor 61)
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