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PH-797804 + tiotropium bromide
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Oral, Inhalation
01
Overview
PH-797804 + tiotropium bromide is an investigational combination therapy evaluated for the treatment of moderate to severe chronic obstructive pulmonary disease (COPD). PH-797804 is an orally administered, small molecule inhibitor of p38 mitogen-activated protein kinase (MAPK), studied for its anti-inflammatory effects. Tiotropium bromide is a long-acting, inhaled antimuscarinic bronchodilator, acting as an antagonist primarily at M3 muscarinic receptors, leading to smooth muscle relaxation and bronchodilation in the airways. The combination aims to improve lung function and reduce COPD symptoms by targeting both airway inflammation (PH-797804) and bronchoconstriction (tiotropium bromide)[2][1][3].
- Other names
- PH-797804 + tiotropium bromide
02
Targets
M1 (Muscarinic acetylcholine receptor M1)CHRM5 (M5)CHRM2 (Muscarinic acetylcholine receptor M2)CHRM4 (M4)CHRM3 (M3)MAPK14 (p38 mitogen-activated protein kinase alpha)
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