Drug intelligence / Profile preview

phentermine + topiramate

Development stage
Approved
Lead developer
VIVUS LLC
Modality
Small Molecules
Administration
Oral
01

Overview

Phentermine + topiramate is a fixed-dose combination of two small molecule drugs used for chronic weight management in adults and adolescents aged 12 years or older with obesity, or overweight individuals with weight-related medical problems. Phentermine is classified as an anorectic (appetite suppressant) that works by decreasing appetite through central nervous system stimulation. Topiramate is an anticonvulsant that also decreases appetite and prolongs feelings of fullness after eating. The combination has demonstrated significant efficacy in promoting weight loss when used alongside a reduced-calorie diet and exercise program. It is marketed under the brand name Qsymia, which was developed to address obesity—a major risk factor for diabetes, hypertension, dyslipidemia, and cardiovascular disease[1][3][4][5].

Brand names
Qsymia
Other names
phentermine/topiramatephentermine and topiramate
02

Targets

GABRR (GABA-A receptor subunit rho)SERT (Sodium-dependent serotonin transporter)iGluR (Ionotropic receptor 76b (Ir76b))NaV (Voltage-gated sodium channels)DAT (Dopamine plasma membrane transport protein)CA2 (Carbonic Anhydrase 2)NET (Norepinephrine Transporter)

Beyond the preview

Go deeper on phentermine + topiramate.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on phentermine + topiramate.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call