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Phentermine + topiramate is a fixed-dose combination of two small molecule drugs used for chronic weight management in adults and adolescents aged 12 years or older with obesity, or overweight individuals with weight-related medical problems. Phentermine is classified as an anorectic (appetite suppressant) that works by decreasing appetite through central nervous system stimulation. Topiramate is an anticonvulsant that also decreases appetite and prolongs feelings of fullness after eating. The combination has demonstrated significant efficacy in promoting weight loss when used alongside a reduced-calorie diet and exercise program. It is marketed under the brand name Qsymia, which was developed to address obesity—a major risk factor for diabetes, hypertension, dyslipidemia, and cardiovascular disease[1][3][4][5].
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