phenyl[1-(n-succinylamino)pentyl]phosphonate

Phenyl[1-(n-succinylamino)pentyl]phosphonate is a synthetic small molecule phosphonate compound, structurally characterized as a transition state analog. It has been widely used in biochemical and structural studies as a hapten to elicit and study catalytic antibodies (abzymes), particularly those with esterase or amidase activity. The compound mimics the transition state of ester hydrolysis, allowing it to bind tightly to antibody active sites designed for catalysis. It is not an approved pharmaceutical drug but serves as an experimental tool in immunochemistry and enzymology research, especially for understanding antibody-catalyzed reactions and optimizing catalytic antibody affinity through phage display techniques[6][7][9].

Other names

3-{[(1R)-1-[hydroxy(phenoxy)phosphoryl]pentyl]carbamoyl}propanoic acidHEP (ligand code)DB07893DB-07893DB 07893