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phenylephrine + apocynin
- Development stage
- Phase 1
- Lead developer
- The University of Texas at Arlington
- Modality
- Small Molecules
- Administration
- Local
01
Overview
Phenylephrine + apocynin is an experimental drug combination used in clinical research to investigate the role of oxidative stress in vascular function. Phenylephrine acts as a selective alpha-1 adrenergic receptor agonist, inducing vasoconstriction. Apocynin is a phytochemical that functions as an inhibitor of NADPH oxidase (NOX), an enzyme responsible for the production of superoxide radicals. By co-administering these agents, researchers at The University of Texas at Arlington aim to determine if NADPH oxidase-derived oxidative stress contributes to the heightened vasoconstrictor responses observed in certain populations, such as Black/African American individuals, which may be linked to increased cardiovascular disease risk.
- Other names
- Phenylephrine and Apocynin
02
Targets
ADRA1A (α1A)NOX4 (NADPH oxidase 4)
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