phleum pratense grass pollen allergen extract + desloratadine

This is a **combination drug** comprising two distinct components: **phleum pratense grass pollen allergen extract** and **desloratadine**. - **Phleum pratense grass pollen allergen extract** is an allergenic extract derived from Timothy grass pollen, commonly used as immunotherapy for the treatment of grass pollen-induced allergic rhinitis and conjunctivitis[1][7]. The mechanism involves administration of controlled allergen doses to induce tolerance by promoting immune modulation, typically increasing IgG antibodies and blunting the seasonal rise of IgE, and reducing hypersensitivity responses[8]. - **Desloratadine** is a second-generation antihistamine that acts as an antagonist at the histamine H1 receptor, blocking histamine-mediated allergic symptoms such as sneezing, itching, and runny nose. It does not cross the blood–brain barrier readily and is less sedating than first-generation antihistamines. The combination is intended for patients suffering from seasonal allergic rhinitis/hay fever due to grass pollen, providing both allergen-specific immunotherapy (disease-modifying) and immediate symptomatic relief[1][3][7].

Brand names

GrazaxAerius

Other names

Phleum pratense allergen extract + desloratadine