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phytoestrogens + isosorbide mononitrate + acetylcysteine
- Development stage
- Unknown
- Lead developer
- Kasr Al Ainy Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Phytoestrogens + isosorbide mononitrate + N-acetyl cysteine refers to a therapeutic approach evaluated in clinical trials where these three agents are used as separate adjuvant arms alongside clomiphene citrate for the treatment of infertility in women with polycystic ovary syndrome (PCOS). Phytoestrogens, such as those derived from *Cimicifuga racemosa*, act as selective estrogen receptor modulators to counteract the anti-estrogenic effects of clomiphene on the endometrium. Isosorbide mononitrate acts as a nitric oxide donor to improve uterine and ovarian blood flow. N-acetyl cysteine serves as an antioxidant and insulin sensitizer, potentially improving follicular development and ovulation rates. This multi-arm strategy aims to overcome clomiphene resistance in anovulatory infertility.
- Brand names
- Klimadynon
- Other names
- Phytoestrogen, NO Donors, N-acetyl Cysteine Add Therapy to Clomiphenecimicifuga racemosa + isosorbide mononitrate + acetylcysteine
02
Targets
ESR1 (ERα)Glutathione and cellular thiol-redox systemMUC (Mucin family)ESR2 (ERβ)sGC (Soluble Guanylyl Cyclase)
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