Drug intelligence / Profile preview

phytosterols + monacolin K

Development stage
Unknown
Lead developer
Difass International
Modality
Small Molecules
Administration
Oral
01

Overview

**phytosterols + monacolin K** is a combination nutraceutical used primarily for lowering cholesterol levels in mildly to moderately hypercholesterolemic patients. Phytosterols inhibit intestinal absorption of cholesterol, reducing the amount of dietary cholesterol entering the bloodstream. Monacolin K, derived from red yeast rice (produced by fermentation with Monascus purpureus), is structurally identical to lovastatin and inhibits HMG-CoA reductase, blocking endogenous cholesterol synthesis in the liver. Together, these ingredients exert additive effects on lowering LDL-cholesterol and apolipoprotein B, reaching clinically significant reductions compared to either agent alone[1][2][3]. The product is often formulated as oral liquid sticks or capsules, with typical daily doses being phytosterols 800–1250 mg and monacolin K 3–10 mg.

Brand names
Dif1statDif-1statDif 1stat
Other names
phytosterols + red yeast ricered yeast rice + plant sterols
02

Targets

NPC1L1 (Niemann-pick C1-Like 1 transporter)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

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