pimecrolimus + clobetasol

Pimecrolimus + clobetasol is a topical combination of two drugs used to treat inflammatory skin conditions. Pimecrolimus is a topical calcineurin inhibitor that decreases inflammation by inhibiting T cell activation and cytokine release, primarily used for mild to moderate atopic dermatitis[1][2][3]. Clobetasol is a potent corticosteroid that reduces inflammation, itching, and redness by activating glucocorticoid receptors and altering gene expression; it is indicated for moderate to severe plaque psoriasis and other corticosteroid-responsive dermatoses[4][5][8]. The combination may be considered in dermatological practice when both immunomodulatory and anti-inflammatory effects are desired.