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piperacillin + tazobactam + azlocillin + latamoxef + meropenem + vancomycin + cefotaxime

Development stage
Unknown
Lead developer
Bayer
Modality
Small Molecules
Administration
Intravenous, Intramuscular
01

Overview

This is a combination of seven antibiotics from different classes, each with distinct mechanisms of action. Such a combination is not marketed as a single pharmaceutical product but may be used in research or highly specialized clinical scenarios for the treatment of severe, multidrug-resistant bacterial infections. The components are: - **Piperacillin** (ureidopenicillin) and **tazobactam** (beta-lactamase inhibitor): Together, they inhibit bacterial cell wall synthesis and protect piperacillin from enzymatic degradation by beta-lactamases[1][2][3]. - **Azlocillin** (ureidopenicillin): A broad-spectrum penicillin antibiotic that inhibits cell wall synthesis. - **Latamoxef** (moxalactam; oxacephem): A beta-lactam antibiotic similar to cephalosporins, inhibiting cell wall synthesis. - **Meropenem** (carbapenem): A broad-spectrum beta-lactam antibiotic effective against many Gram-positive and Gram-negative bacteria by inhibiting cell wall synthesis. - **Vancomycin** (glycopeptide): Inhibits bacterial cell wall biosynthesis by binding to D-Ala-D-Ala terminus of peptidoglycan precursors. - **Cefotaxime** (third-generation cephalosporin): Inhibits bacterial cell wall synthesis. This combination would provide extremely broad antibacterial coverage, including activity against many resistant organisms. However, such use would be reserved for life-threatening infections where multidrug resistance is confirmed or strongly suspected.

02

Targets

β-lactamaseD-Ala-D-Ala (D-Ala-D-Ala terminus)PBP (Penicillin-binding protein family)

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