Drug intelligence / Profile preview

pitavastatin + fenofibrate

Development stage
Phase 4
Lead developer
Withus Group
Modality
Small Molecules
Administration
Oral
01

Overview

Taspeno is a fixed-dose combination (FDC) pharmaceutical product containing pitavastatin and fenofibrate. Pitavastatin is a third-generation statin that inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis, thereby reducing LDL cholesterol levels. Fenofibrate is a fibric acid derivative that acts as an agonist for the peroxisome proliferator-activated receptor alpha (PPARα), which increases the lipolysis of triglyceride-rich particles and stimulates the synthesis of HDL cholesterol. This combination is typically used to treat mixed dyslipidemia in patients who require management of both elevated cholesterol and triglyceride levels. It is marketed by Withus Group in South Korea.

Brand names
Taspeno
Other names
Taspeno Capsule
02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)NR1H3 (Liver X receptor beta)PPARA (Peroxisome proliferator-activated receptor alpha)PPARG (Peroxisome proliferator-activated receptor gamma)

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