placebo + progesterone

The combination of placebo and progesterone refers to a specific treatment arm used in clinical trials conducted by the Centre for Reproductive Medicine (CRG) at UZ Brussel, particularly in studies comparing oral dydrogesterone to micronized vaginal progesterone for luteal phase support. In this double-dummy, crossover study design, participants in this arm receive active micronized progesterone (typically 200 mg capsules administered vaginally three times daily) and a matching placebo oral tablet that is indistinguishable from dydrogesterone. Progesterone is a naturally occurring steroid hormone that plays a crucial role in the luteal phase of the menstrual cycle by inducing secretory changes in the estrogen-primed endometrium, thereby supporting embryo implantation and the maintenance of early pregnancy in women undergoing assisted reproductive technology (ART).

Other names

placebo + micronized progesteroneplacebo dydrogesterone + micronized progesteroneplacebo + progesterone-CRG UZ Brussel-infertility