placebo + saline-University of Minnesota-tinnitus

placebo + saline-University of Minnesota-tinnitus refers to the placebo control arm of a Phase 2 randomized, placebo-controlled clinical trial sponsored by the University of Minnesota. In this study, participants receive injections of preservative-free normal saline into the anterior, superior, and posterior auricular muscles. This arm serves as the comparator for incobotulinumtoxinA (Xeomin), which is being evaluated for its potential to alleviate tinnitus symptoms. The trial utilizes the Tinnitus Handicap Inventory (THI) to measure outcomes. As a placebo, the saline solution lacks a specific pharmacological mechanism for treating tinnitus and is used to control for the effects of the injection procedure and participant expectation.

Other names

Placebo-Salinepreservative free normal saline