Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
plant sterol esters + eicosapentaenoic acid + docosahexaenoic acid
- Development stage
- Unknown
- Lead developer
- Cultech
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
This combination therapy targets dyslipidemia by utilizing two distinct mechanisms. Plant sterol esters, which are structurally similar to cholesterol, competitively inhibit the absorption of dietary and biliary cholesterol in the small intestine by interacting with the Niemann-Pick C1-like 1 (NPC1L1) transporter, thereby reducing low-density lipoprotein (LDL) cholesterol levels. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are long-chain omega-3 fatty acids that primarily reduce serum triglyceride levels. They act as agonists for peroxisome proliferator-activated receptor alpha (PPAR-alpha) and inhibit diacylglycerol O-acyltransferase (DGAT), leading to decreased hepatic very-low-density lipoprotein (VLDL) synthesis and increased fatty acid oxidation. This combination is widely used in dietary supplements and functional foods to provide a synergistic approach to cardiovascular health by addressing both cholesterol and triglyceride levels.
- Brand names
- Swanson Omega-3 & Plant SterolsBlackmores Cholesterol HealthCardio-Sterol
- Other names
- phytosterol esters + EPA + DHAomega-3 fatty acids + plant sterolsplant sterols + fish oil
02
Targets
NPC1L1 (Niemann-pick C1-Like 1 transporter)PPARA (Peroxisome proliferator-activated receptor alpha)DGAT1 (Diacylglycerol O-acyltransferase 1)SREBP-1 / SREBF1 (SREBP-1)
Beyond the preview
Go deeper on plant sterol esters + eicosapentaenoic acid + docosahexaenoic acid.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on plant sterol esters + eicosapentaenoic acid + docosahexaenoic acid.