Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
plasminogen, human-tvmh
- Development stage
- Approved
- Lead developer
- Kedrion Biopharma
- Modality
- Recombinant Proteins and Enzymes
- Administration
- intravenous
01
Overview
Plasminogen, human-tvmh (marketed as Ryplazim) is a plasma-derived human Glu-plasminogen concentrate indicated for the treatment of patients with plasminogen deficiency type 1 (hypoplasminogenemia). It is the first and only FDA-approved specific treatment for this ultra-rare genetic disorder, which is characterized by abnormally low plasminogen levels and activity, leading to the formation of fibrin-rich, ligneous pseudomembranous lesions on mucous membranes throughout the body. Ryplazim acts as a protein replacement therapy, temporarily restoring physiological plasminogen levels and re-establishing normal fibrinolytic activity to break down and resolve these lesions. It is administered intravenously.
- Brand names
- Ryplazim
- Other names
- Glu-plasminogenIV PLG concentratehuman plasma-derived Glu-plasminogenhuman plasma-derived plasminogenplasminogen (human)plasminogen, human-tvmh
02
Targets
Fibrin (Factor Ia)
Beyond the preview
Go deeper on plasminogen, human-tvmh.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on plasminogen, human-tvmh.