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platelet-rich plasma (University of Toledo Health Science Campus)
- Development stage
- Unknown
- Lead developer
- University of Toledo Health Science Campus
- Administration
- Intraarticular
01
Overview
Platelet-rich plasma (PRP) is an autologous biological therapy being investigated by the University of Toledo Health Science Campus for the treatment of knee osteoarthritis. The preparation involves concentrating platelets from a patient's own peripheral blood to create a substance rich in growth factors, including platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), and vascular endothelial growth factor (VEGF). When injected intra-articularly into the knee joint, these factors are thought to modulate the inflammatory environment, stimulate cellular proliferation, and promote tissue repair within the cartilage and synovium. The specific clinical program at the University of Toledo focuses on establishing standardized clinical guidelines by correlating the specific concentrations of PRP components with patient outcomes, opioid use, and emergency department utilization.
- Other names
- PRPPlatelet Rich Plasma InjectionAutologous Platelet Rich Plasma
02
Targets
IGF-1R (Insulin-like growth factor 1 receptor)PDGFRA (Platelet-derived growth factor receptor alpha)FGFR3 (Fibroblast growth factor receptor 3)TGFBR (TGF-beta receptor)
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