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platelet-rich plasma + endometrial cells
- Development stage
- Preclinical
- Modality
- Tissue Cells → Other Cell Types → Cell Therapies, Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems, Stem Cell Therapies → Cell Therapies
- Administration
- Hysteroscopic, Intrauterine
01
Overview
This therapy is an experimental regenerative treatment that combines autologous platelet-rich plasma (PRP) with autologous endometrial cells, typically administered via hysteroscopic or intrauterine injection. PRP is derived from the patient's own blood and contains a high concentration of platelets, growth factors (such as VEGF, EGF, PDGF, TGF), and cytokines that stimulate tissue repair, angiogenesis, cell proliferation, and anti-inflammatory effects. The addition of autologous endometrial cells aims to further enhance regeneration by directly supplying functional cellular components to the uterine lining. This combination is being investigated for improving endometrial receptivity in patients with refractory thin endometrium or recurrent implantation failure during assisted reproductive technology (ART) cycles[6][1][3]. The mechanism involves promoting local tissue repair and regeneration through synergistic action of growth factors from PRP and direct cellular contribution from transplanted endometrial cells.
- Other names
- platelet-rich plasma and endometrial cellsPRP + endometrial cells
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