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platelet-rich plasma + platelet-poor plasma

Development stage: Unknown
Lead developer: Shahid Beheshti University of Medical Sciences
Administration: Intraarticular, Intradermal, Intramuscular, Intralesional, Topical

Overview

Platelet-rich plasma (PRP) and platelet-poor plasma (PPP) are blood components with different platelet concentrations used in regenerative medicine. PRP contains a high concentration of platelets (6-8 times normal levels) that release growth factors to stimulate tissue healing. PPP has a very low platelet count (<10 x 10³/μL) but contains fibrinogen and other proteins that can form fibrin-rich clots to facilitate cell migration and attachment. When used together, they provide complementary benefits: PRP delivers concentrated growth factors for accelerated healing, while PPP offers anti-inflammatory properties and provides a scaffold for tissue regeneration. This combination is used to treat various musculoskeletal injuries, promote wound healing, and support tissue regeneration.

Other names: PRP + PPP

Targets

VEGFR2 (Vascular endothelial growth factor receptor 2)PDGFRA (Platelet-derived growth factor receptor alpha)MET (Mesenchymal-epithelial transition factor receptor)TGFBR3 (TGF-β receptor type III)PDGFRB (Platelet-derived growth factor receptor beta)GPIIb/IIIa (Integrin alpha-IIb/beta-3)EGFR T790M (Epidermal growth factor receptor T790M mutant)IGF-1R (Insulin-like growth factor 1 receptor)

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