platelet transfusion (Yale University)

Platelet transfusion is a biological therapy involving the intravenous administration of platelet concentrates to prevent or treat bleeding in patients with thrombocytopenia or platelet dysfunction. Platelets are cell fragments derived from megakaryocytes that play a critical role in primary hemostasis by adhering to sites of vascular injury, aggregating to form a platelet plug, and providing a surface for the assembly of coagulation factor complexes. In the context of the ECSTATIC trial led by Yale University, researchers are investigating optimal hemostatic transfusion strategies for critically ill children supported by extracorporeal membrane oxygenation (ECMO). The study specifically compares higher versus lower platelet count thresholds for triggering prophylactic transfusions to balance the prevention of hemorrhage against the potential morbidity and mortality associated with large-volume transfusions in this vulnerable population.

Other names

thrombocyte transfusionplatelet concentrateplatelets