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PLCL + Fg group

Development stage: Unknown
Modality: Recombinant Proteins and Enzymes, Hydrogel Systems → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration: Topical

Overview

PLCL + Fg group refers to a combination wound dressing composed of electrospun poly(L-lactide-co-caprolactone) (PLCL), a biodegradable synthetic copolymer, and formulated porcine fibrinogen (Fg). This advanced wound care product is designed for topical application in the treatment of diabetic foot ulcers (DFUs). The mechanism involves providing a biocompatible scaffold that supports cell migration and tissue regeneration while the fibrinogen component aids in hemostasis and further promotes healing. In clinical trials, this combination has demonstrated beneficial effects on wound surface reduction and regulation of the wound microenvironment compared to standard alginate dressings[1].

Other names: poly(L-lactide-co-caprolactone) and formulated porcine fibrinogen dressingPLCL/Fg dressing

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