Drug intelligence / Profile preview

policresulen + cinchocaine hydrochloride

Development stage
Unknown
Lead developer
Takeda
Modality
Small Molecules
Administration
Topical, Rectal
01

Overview

Policresulen + cinchocaine hydrochloride is a fixed-dose combination topical therapy primarily used in proctology for the treatment of hemorrhoids and other anorectal conditions. Policresulen is a polycondensation product of metacresolsulfonic acid and formaldehyde that acts as a selective hemostatic and antiseptic agent; it works by coagulating necrotic or pathologically altered tissue while leaving healthy tissue intact, thereby promoting wound healing and preventing infection. Cinchocaine hydrochloride (also known as dibucaine) is a potent, long-acting local anesthetic of the amide type that provides symptomatic relief from pain and itching by blocking the initiation and conduction of nerve impulses through the inhibition of voltage-gated sodium channels. The combination is typically available as an ointment or suppository for rectal or perianal application.

Brand names
Faktu
Other names
policresulen and cinchocaine hydrochloridedibucaine and policresulen
02

Targets

SCN5A (Sodium channel protein type 5 subunit alpha)CaM (Calmodulin)SCN10A (Sodium channel protein type X alpha subunit)

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