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polidocanol + urea
- Development stage
- Unknown
- Lead developer
- Almirall
- Modality
- Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Hydrogel Systems → Drug Delivery Systems
- Administration
- Topical
01
Overview
Polidocanol + urea is a topical combination used primarily in dermatology for the symptomatic relief of pruritus (itching) and the treatment of dry skin conditions. Polidocanol acts as a local anesthetic and antipruritic agent, though its exact mechanism for itch relief is not fully defined; it may reduce nerve irritation and has mild anesthetic properties. Urea is a keratolytic and humectant that improves skin hydration by increasing water uptake in the stratum corneum, softening hyperkeratotic areas, and enhancing desquamation. The combination leverages both agents' effects to relieve itching while improving skin moisture barrier function. This combination is commonly found in over-the-counter creams such as Optiderm or Balneum Plus for eczema, xerosis (dry skin), atopic dermatitis, psoriasis, ichthyosis, and other pruritic dermatoses[3][4]. **Developers:** Almirall **Manufacturers:** Almirall
- Brand names
- OptidermBalneum Plus
- Other names
- polidocanol + ureapolidocanol/urealaureth-9 + urea
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