poly (acetyl, arginyl) glucosamine

Poly (acetyl, arginyl) glucosamine is a **glycopolymer** with demonstrated **antimicrobial** and **mucolytic** properties[1][6]. It possesses bactericidal activity against a broad spectrum of bacteria, including Gram-positive and Gram-negative species, and is effective at disrupting biofilms, notably those formed by Pseudomonas aeruginosa[1][6]. It is derived from chitin sourced from Arctic shrimp shells and formulated as a soluble powder with a molecular weight of 20 to 100 kDa[7]. The agent is used primarily as a **topical wound rinse** for the treatment of infected or chronic dermal and foot lesions in elephants and rhinoceroses, as an FDA-indexed (not FDA-approved) veterinary product[5][7]. Its mechanisms of action include direct antimicrobial effects (disrupting bacterial membranes and biofilms) and mucolytic activities, normalizing mucus viscosity in disease states with thickened mucus[1][6]. No systemic toxicity or mutagenicity has been observed in preclinical animal models[5].

Brand names

Synoplex

Other names

poly-N (acetyl, arginyl) glucosamine