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poly-ICLC + peptide-pulsed dendritic cell vaccine
- Development stage
- Unknown
- Lead developer
- Medical University of South Carolina
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Peptides, Vaccines & Immunotherapeutics
- Administration
- Intradermal, Intramuscular
01
Overview
This investigational cancer immunotherapy, developed at the Medical University of South Carolina, consists of autologous dendritic cells pulsed with three tumor-associated antigen peptides (hTERT, CEA, and survivin) and administered alongside the TLR3 agonist adjuvant Poly-ICLC (Hiltonol). The vaccine is designed to induce and expand tumor-specific CD8+ T-cell responses in HLA-A2+ patients. It has been primarily evaluated for the treatment of metastatic or locally advanced unresectable pancreatic adenocarcinoma, where it demonstrated safety and the ability to elicit measurable immune responses in early-phase clinical testing.
- Other names
- Poly-ICLC and Peptide-pulsed DC VaccinehTERT/CEA/survivin peptide-pulsed dendritic cell vaccineHiltonol and peptide-pulsed dendritic cell vaccine
02
Targets
T-cell receptor recognizing survivin SRV.A2/HLA-A2 peptide-MHC complexTLR3 (Toll-like receptor 3)
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