polydopamine + resveratrol + hyaluronidase

A **combination nanomedicine composed of polydopamine nanoparticles loaded with resveratrol and hyaluronidase**, developed as a tumor stroma-modulating drug delivery system. **Polydopamine** serves as a biocompatible nanocarrier, facilitating co-delivery and sustained release of **resveratrol** (a chemotherapeutic agent with antioxidant and pro-apoptotic effects) and **hyaluronidase** (an enzyme that degrades hyaluronic acid in the tumor extracellular matrix). The combination aims to degrade the hyaluronic acid-rich, dense stromal barrier that restricts drug permeability in tumors, thereby **enhancing the deep penetration and cytotoxic efficacy of resveratrol within solid tumors, with a focus on pancreatic cancer**. This approach exploits the **synergy between ECM modulation by hyaluronidase and cytotoxicity by resveratrol**, delivered via polydopamine nanoparticles for targeted, EPR-mediated accumulation and release in the tumor microenvironment[1][3][5][7].

Other names

PDA@Res@HAase