polyethylene glycol + linaclotide

Polyethylene glycol + linaclotide is a combination regimen used primarily for bowel preparation prior to colonoscopy, especially in patients with chronic constipation or irritable bowel syndrome. Polyethylene glycol (PEG) is an osmotic laxative that retains water in the stool, resulting in softer stools and increased bowel movements. Linaclotide is a guanylate cyclase-C agonist that increases intestinal fluid secretion and accelerates transit by stimulating cyclic GMP production on the luminal surface of the intestinal epithelium. The combination aims to improve both efficacy and tolerability of bowel cleansing compared to high-volume PEG alone, offering similar or superior cleansing quality with reduced adverse effects such as abdominal discomfort, bloating, nausea, and vomiting[1][2][3][4][5][6].

Other names

polyethylene glycol + linaclotide