polyethylene glycol 3350 + sodium bicarbonate + sodium chloride + potassium chloride

This drug is a sulfate-free osmotic laxative combination used primarily for rapid bowel cleansing prior to colonoscopy or barium enema X-ray examinations. It consists of **polyethylene glycol (PEG) 3350**, a non-absorbable polymer, combined with a specific blend of electrolytes: **sodium bicarbonate**, **sodium chloride**, and **potassium chloride**. The mechanism of action relies on the osmotic activity of PEG 3350, which retains water in the intestinal lumen to induce a watery diarrhea that effectively clears the colon. The electrolyte composition is formulated to make the solution isosmotic with body fluids, ensuring that the administration of large volumes (typically 4 liters) results in virtually no net absorption or excretion of ions or water. This sulfate-free formulation was specifically developed by **Braintree Laboratories** (as NuLYTELY) to improve the taste and palatability compared to original PEG-electrolyte solutions (like GoLYTELY), thereby enhancing patient adherence and acceptance.

Brand names

NuLYTELYGaviLyte-NColopegTransipegTransipegLib

Other names

PEG-3350 and electrolytes (sulfate-free)macrogol 3350 and electrolytesmacrogol3350 and electrolytesmacrogol-3350 and electrolytessulfate-free PEG-electrolyte solutionpolyethylene glycol 3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution