polyribosylribitol phosphate + tetanus toxoid

This **combination vaccine** consists of purified **polyribosylribitol phosphate (PRP)**, the capsular polysaccharide from *Haemophilus influenzae* type b (Hib), **conjugated to tetanus toxoid** as a carrier protein. The conjugation makes the polysaccharide **T-cell dependent**, substantially enhancing immunogenic response in infants and young children compared to unconjugated polysaccharide vaccines[3][5][6]. The vaccine induces potent anti-PRP antibody production that protects against invasive Hib disease such as meningitis and pneumonia. The use of tetanus toxoid as a protein carrier also primes for tetanus immunity. This vaccine is administered to infants and young children, usually as part of routine immunization schedules, and can be formulated alone or with other vaccine components[1][3][5].

Brand names

PRP-TTETRAct-HIB

Other names

polyribosylribitol phosphate-tetanus protein conjugatePRP-THib PRP-THaemophilus influenzae type b conjugate vaccine (tetanus toxoid conjugate)Hib-TT