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Drug intelligence / Profile preview
ponatinib + mini-hyper-CVD + venetoclax
- Development stage
- Unknown
- Lead developer
- University of Texas MD Anderson Cancer Center
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
This investigational combination regimen is being evaluated in a Phase II clinical trial at the M.D. Anderson Cancer Center for the treatment of relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL). The regimen integrates three distinct therapeutic strategies: **ponatinib**, a multi-targeted tyrosine kinase inhibitor that inhibits BCR-ABL and other relevant kinases; **venetoclax**, a selective BCL-2 inhibitor that promotes apoptosis; and **mini-hyper-CVD**, a dose-attenuated chemotherapy backbone. Mini-hyper-CVD consists of cyclophosphamide, vincristine, and dexamethasone alternating with methotrexate and cytarabine. By combining targeted kinase inhibition, apoptotic sensitization, and cytotoxic chemotherapy, the regimen aims to overcome resistance mechanisms and improve complete remission rates in patients with advanced T-ALL.
- Other names
- Ponatinib, Mini-hyper-CVD, and VenetoclaxMini-hyper-CVD plus ponatinib and venetoclaxMini-HCVD-Pon-Ven
02
Targets
Bcl-w (B-cell lymphoma 2-like 2)BCL2L1 (B-cell lymphoma-extra large protein)BCR-ABL1 (Breakpoint cluster region-Abelson tyrosine-protein kinase 1)DNADNA polymerase familyDHFR (Dihydrofolate reductase)FGFR1 (Fibroblast growth factor receptor 1)GR (Glucocorticoid receptor)PDGFRA (Platelet-derived growth factor receptor alpha)SRC (Proto-oncogene tyrosine-protein kinase Src)TUBB (Tubulin (alpha and beta subunits))VEGFR2 (Vascular endothelial growth factor receptor 2)BCL-2 (BCL-2 family)ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase)
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