Drug intelligence / Profile preview

poria + gamma-aminobutyric acid

Development stage
Preclinical
Lead developer
Yunnan Botanee Bio-Technology Group
Modality
Small Molecules
Administration
Oral
01

Overview

**poria + gamma-aminobutyric acid** is an oral multi-ingredient dietary supplement that combines extracts of *Poria cocos* (a fungus used in traditional medicine) with gamma-aminobutyric acid (GABA), the key inhibitory neurotransmitter in the mammalian central nervous system. It is typically developed as part of integrative or functional medicine approaches for improving sleep quality and, potentially, skin health. Randomized controlled trials indicate that combinations containing Poria cocos, GABA, and other botanicals can lead to clinically significant improvements in sleep parameters and skin hydration, without reported adverse effects. The purported mechanism is the synergistic anxiolytic and sleep-promoting effect, attributed both to GABAergic activity (via GABA receptors in the CNS) and possible adaptogenic or sedative effects from *Poria cocos*. These products are generally categorized as dietary supplements rather than pharmaceuticals and are not approved for treatment or prevention of disease but may be marketed for wellness benefits and sleep support[4][5].

Other names
poria + GABAPoria cocos + gamma-aminobutyric acidporia supplement with GABA
02

Targets

GABRR (GABA-A receptor subunit rho)GABA-B (Gamma-aminobutyric acid receptor type B)

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