Drug intelligence / Profile preview

potassium citrate + magnesium citrate + pyridoxine hydrochloride

Development stage
Approved
Lead developer
SSK Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

PM-B6 is an oral combination therapy developed by SSK Pharma for the treatment and prevention of kidney stones (nephrolithiasis). It is formulated as a syrup containing potassium citrate, magnesium citrate, and pyridoxine hydrochloride (vitamin B6). Potassium citrate and magnesium citrate act as urinary alkalinizers and stone inhibitors; citrate binds to urinary calcium to prevent the formation of calcium oxalate crystals, while magnesium binds to oxalate to form soluble complexes, reducing the supersaturation of calcium oxalate. Pyridoxine hydrochloride is included to prevent vitamin B6 deficiency, which is associated with increased endogenous synthesis of oxalate. Together, these components raise urinary pH and citrate levels, inhibiting the crystallization, growth, and aggregation of stone-forming minerals in the kidneys.

Brand names
PM-B6PM-B-6PM-B 6PM-B6 400mlPM-B-6 400mlPM-B 6 400ml
Other names
potassium citrate + magnesium citrate + pyridoxinepotassium citrate + magnesium citrate + pyridoxine HClpotassium citrate + magnesium citrate + pyridoxine hydrochloridepotassium citrate + magnesium citrate + vitamin B6
02

Targets

SPT (Serine palmitoyltransferase)

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