Drug intelligence / Profile preview

potassium nitrate + strontium chloride + paeonol

Development stage
Unknown
Lead developer
West China Hospital of Stomatology, Sichuan University
Modality
Small Molecules
Administration
Dental, Topical
01

Overview

This is a combination of three active ingredients—potassium nitrate, strontium chloride, and paeonol—primarily formulated as a toothpaste for the management of dentine hypersensitivity (DH). Potassium nitrate acts by depolarizing nerve endings in the dental pulp to reduce pain transmission. Strontium chloride works by occluding dentinal tubules, thereby blocking external stimuli from reaching nerves. Paeonol is a natural compound with anti-inflammatory and analgesic properties, derived from the root bark of Paeonia suffruticosa. Clinical trials have demonstrated that this combination significantly reduces symptoms of dentine hypersensitivity compared to placebo toothpaste[1][2][3]. The product is considered a novel functional ingredient blend for anti-hypersensitivity oral care.

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