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povidone-iodine + lidocaine
- Development stage
- Preclinical
- Modality
- Hydrogel Systems → Drug Delivery Systems, Small Molecules
- Administration
- Topical, Ophthalmic
01
Overview
**povidone-iodine + lidocaine** is an ophthalmic topical combination product being developed as a **thermoresponsive gel depot** for **pre-intravitreal injection antisepsis and anesthesia**. The formulation combines **lidocaine**, a local anesthetic that decreases ocular surface sensitivity, with **povidone-iodine**, a broad-spectrum antiseptic that releases free iodine and kills microorganisms on the ocular surface. It is administered as a liquid into the lower fornix and transitions at body temperature into a stable gel, enabling single-step delivery of anesthesia and antisepsis before intravitreal injection procedures for retinal diseases. Based on the provided context, the product is an investigational combined delivery system designed to avoid the reduced antiseptic efficacy that can occur when lidocaine gel and povidone-iodine are applied sequentially.
- Other names
- povidone-iodine + lidocaineL/PI-Gellidocaine + povidone-iodine gelthermoresponsive lidocaine and povidone-iodine gel
02
Targets
NaV (Voltage-gated sodium channels)
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