prasterone enanthate + estradiol valerate

This drug is a **combination injectable formulation** consisting of **estradiol valerate**, a synthetic estrogen, and **prasterone enanthate** (DHEA enanthate), a weak androgen, estrogen, and neurosteroid. It is used as **menopausal hormone therapy in women** to treat menopausal symptoms. Estradiol valerate acts as an estrogen receptor agonist, while prasterone enanthate serves as a long-acting prodrug of prasterone (DHEA), providing mild androgenic, estrogenic, and neurosteroid effects. The combination aims to relieve estrogen deficiency symptoms while also potentially providing psychotropic benefits without masculinizing effects at standard doses. Given via intramuscular injection, the medication is formulated in oil solution, typically administered every 4–6 weeks. It was first described in 1972, introduced for medical use in 1975, and is available in several countries in Europe, Latin America, and Egypt[1][2][3].

Brand names

Gynodian DepotBinodian DepotCidodian DepotKlimaxSupligol NF

Other names

estradiol valerate/prasterone enanthateEV/DHEA-EEV/PESH-70833-DSH70833-DSH 70833-D