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Precision cells (Shanghai International Medical Center)
- Development stage
- Unknown
- Lead developer
- Shanghai International Medical Center
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, Tumor-Infiltrating Lymphocytes (TILs) → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Subcutaneous, Intravenous
01
Overview
Precision cells is an autologous cell-based immunotherapy protocol developed by Shanghai International Medical Center for the treatment of advanced malignancies, including lung and liver cancer. The therapy utilizes a combination of dendritic cells (DC) and a specialized mixture of activated immune cells known as PNAT (Patient-specific Natural killer cell and Activated T cell) and PMAT (Patient-specific Memory Activated T cell). The dendritic cells are administered via subcutaneous injection to prime the immune system by presenting tumor-associated antigens, while the PNAT and PMAT cells are infused intravenously to provide direct, broad-spectrum cytotoxic activity against cancer cells. This multi-component approach is designed to overcome tumor-induced immunosuppression and is typically evaluated in combination with standard-of-care treatments like chemotherapy or transcatheter arterial chemoembolization (TACE).
- Other names
- Precision Cell ImmunotherapyDC+PNAT/PMAT cell therapy
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