prednisolone + prednisone

Prednisolone + prednisone is a combination of two synthetic glucocorticoid corticosteroids, both of which are used for their anti-inflammatory and immunosuppressive properties. Prednisone is a prodrug that must be converted in the liver to its active form, prednisolone. Both drugs act by binding to the glucocorticoid receptor, inhibiting pro-inflammatory signals and promoting anti-inflammatory effects. They are commonly prescribed for a wide range of conditions including autoimmune diseases (such as rheumatoid arthritis and lupus), severe allergies, asthma, skin disorders, certain cancers (like leukemia), inflammatory bowel disease, and adrenal insufficiency[1][3][5][6][7]. The combination itself is not standard clinical practice since both drugs have overlapping mechanisms; typically one or the other is prescribed based on patient-specific factors such as liver function[7]. However, if administered together (for example during transitions or special clinical circumstances), their combined effect would be additive in terms of glucocorticoid activity.

Brand names

DeltasoneRayosSterapredOrapredPediapredPrelone

Other names

prednisoneprednisolone