prednisone + prednisolone

Prednisone and prednisolone are synthetic glucocorticoid corticosteroids used for their potent anti-inflammatory, immunosuppressive, and lymphocytotoxic properties. Prednisone is a prodrug that is rapidly converted by the liver into its active metabolite, prednisolone. In oncology, they are frequently utilized as components of multi-agent chemotherapy regimens for hematologic malignancies, such as classical Hodgkin Lymphoma (cHL), where they exert direct lymphocytotoxic effects by inducing apoptosis in malignant lymphoid cells. Their mechanism involves binding to the cytosolic glucocorticoid receptor (GR), which then translocates to the nucleus to modulate the transcription of genes involved in inflammation, cell survival, and cytokine production.

Brand names

DeltasoneRayosMillipredOrapredPediapredPrelone

Other names

prednisoneprednisoloneglucocorticoids